Drug Utilization Evaluation of Imipenem and Assessing the Role of Pharmacist Interventions

Background and purpose: This study aimed at evaluating utilization of imipenem and assessing the role of pharmacist in rational use of antibiotics. Materials and methods: A retrospective/prospective observational study was conducted in Ramsar Imam Sajjad Hospital in 59 patients receiving imipenem, 2018-2019. In retrospective phase, patients’ records were reviewed, while in prospective phase, a pharmacist provided recommendations on use of imipenem. Duration of taking imipenem, dosage, and dosage adjustment in renal insufficiency were compared with standard protocols. Results: Mean age of the patients was 69.89±16.12 years and there were 29 males. The most common reason for prescribing imipenem was lower respiratory tract infection (54%) which was more used in internal medicine ward (67.28%) ordered by infectious diseases specialist (65%). In retrospective and prospective phases, mean dosage of imipenem, duration of receiving the antibiotic, and dosage adjustment in renal insufficiency were according to standard protocols in 65% and 85%,  45% and 65%, and 60% and 90% of the cases, respectively (P<0.001). Conclusion: The role of pharmacist in drug utilization evaluations is of great importance for optimal use of drugs and reducing mortality rates caused by infectious diseases.